NFL odds, lines, picks, top predictions for Week 1, 2021: Computer model backing 49ers, Panthers

Extra Individuals will place NFL bets this season than ever earlier than, in keeping with the American Gaming Affiliation. It estimates that 45.2 million Individuals plan to wager on the upcoming season, which continues on Sunday with a loaded Week 1 NFL schedule. The Rams are at present 7.5-point favorites in opposition to the Bears on Sunday Night time Soccer, in keeping with the newest Week 1 NFL odds from Caesars Sportsbook.

Will Los Angeles deal with enterprise at dwelling, or must you look to the underdog as one in all your Week 1 NFL predictions? There are many video games to wager on, many with tight Week 1 NFL spreads. The entire Week 1 NFL lines are listed under, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 1 NFL picks now

The mannequin, which simulates each NFL sport 10,000 instances, is up virtually $7,900 for $100 gamers on top-rated NFL picks since its inception six years in the past. It went a scorching 24-14 on top-rated NFL picks final season, returning greater than $800. The mannequin additionally enters the 2021 season on an unimaginable 120-78 run on top-rated NFL picks that dates again to the 2017 season.

The mannequin additionally ranked within the High 10 on NFLPickWatch 4 of the previous 5 years on straight-up NFL picks and beat greater than 94 p.c of CBS Sports activities Soccer Decide’em gamers 4 instances throughout that span. Anybody who has adopted it’s means up.

Now, it has turned its consideration to the newest Week 1 NFL odds from Caesars and locked in picks for each NFL matchup. Head here to see every pick.

High Week 1 NFL predictions

One of many high Week 1 NFL predictions the mannequin recommends: The 49ers (-7.5) cowl the unfold in opposition to the Lions. The Lions are opening the season underneath first-year head coach Dan Campbell with low expectations. They’re depleted on the defensive facet of the ball and quarterback Matthew Stafford is now with the Rams. San Francisco has a passing sport that may benefit from a sieve-like protection.

The 49ers even have a robust dashing assault, so they need to management this sport from begin to end. Detroit wants a robust day from quarterback Jared Goff its offense, but it surely won’t rating sufficient factors to cowl this quantity, in keeping with the mannequin. In truth, SportsLine’s NFL mannequin has San Francisco cashing unfold tickets in effectively over 50 p.c of simulations. 

One other one of many high Week 1 NFL picks from the mannequin: The Panthers (-5.5) cowl as dwelling favorites in opposition to the Jets. Quarterback Sam Darnold has by no means had a lot energy alongside him throughout his NFL profession, however now he has star working again Christian McCaffrey within the backfield. McCaffrey missed most of final season and was taken because the No. 1 general Fantasy soccer decide in most drafts. Darnold has the revenge issue on his facet as he will get able to go up in opposition to his former workforce.

New York is enjoying underneath a first-year head coach, so it would take the Jets time to develop chemistry. They’ve a shaky secondary that Darnold ought to have success in opposition to. SportsLine’s mannequin has Carolina protecting this quantity in effectively over 50 p.c of simulations. 

Tips on how to make Week 1 NFL picks 

The mannequin has additionally made the decision on who wins and covers in each different sport on the Week 1 NFL schedule, and it is calling for a Tremendous Bowl contender to go down exhausting. You can only get every pick for every game at SportsLine.

So what NFL picks are you able to make with confidence? And which Tremendous Bowl contender goes down exhausting? Take a look at the newest NFL odds under, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,900 since its inception, and discover out.

Week 1 NFL odds (by way of Caesars)

Sunday, Sept. 12

Steelers at Bills (-6.5, 48.5)

Featured Sport | Buffalo Payments vs. Pittsburgh Steelers

Jets at Panthers (-5.5, 44.5)

Featured Sport | Carolina Panthers vs. New York Jets

Jaguars at Texans (+2.5, 44.5)

Featured Sport | Houston Texans vs. Jacksonville Jaguars

Cardinals at Titans (-3. 52)

Featured Sport | Tennessee Titans vs. Arizona Cardinals

Chargers at Washington (+1, 44.5)

Featured Sport | Washington Soccer Staff vs. Los Angeles Chargers

Eagles at Falcons (-3, 48)

Featured Sport | Atlanta Falcons vs. Philadelphia Eagles

Seahawks at Colts (+2.5, 49.5)

Featured Sport | Indianapolis Colts vs. Seattle Seahawks

Vikings at Bengals (+3, 47.5)

Featured Sport | Cincinnati Bengals vs. Minnesota Vikings

49ers at Lions (+7.5, 45)

Featured Sport | Detroit Lions vs. San Francisco 49ers

Browns at Chiefs (-6, 54.5)

Featured Sport | Kansas Metropolis Chiefs vs. Cleveland Browns

Dolphins at Patriots (-3, 43.5)

Featured Sport | New England Patriots vs. Miami Dolphins

Broncos at Giants (+3, 42)

Featured Sport | New York Giants vs. Denver Broncos

Packers at Saints (+4, 50)

Featured Sport | New Orleans Saints vs. Inexperienced Bay Packers

Bears at Rams (-7.5, 46.5)

Featured Sport | Los Angeles Rams vs. Chicago Bears

Monday, Sept. 13

Ravens at Raiders (+4.5, 50.5)

Featured Sport | Las Vegas Raiders vs. Baltimore Ravens | NFL odds, traces, picks, high predictions for Week 1, 2021: Laptop mannequin backing 49ers, Panthers


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