NFL odds, lines, picks, spreads, best bets, predictions for Week 1, 2021: Top model backing 49ers, Panthers

Contemporary off a 13-3 season and a visit to the AFC Championship Recreation, the Buffalo Payments might be examined to start out the 2021 NFL schedule as they host the Pittsburgh Steelers. That is one in all 5 video games between playoff groups from a season in the past, and the Payments are 6.5-point favorites within the Week 1 NFL odds from Caesars Sportsbook. Solely the Rams and 49ers are larger favorites, with the Week 1 strains exhibiting Los Angeles favored by 7.5 over Chicago and San Francisco favored by 8.5 over Detroit.

Along with the 5 matchups between playoff groups, there are two divisional matchups, with the Jaguars favored by three over the Texans and the Patriots favored by a subject purpose over the Dolphins within the Week 1 NFL spreads. Which approach do you have to lean on all 15 remaining video games as you make your Week 1 NFL bets? All the Week 1 NFL lines are listed under, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 1 NFL picks now

The mannequin, which simulates each NFL recreation 10,000 instances, is up virtually $7,900 for $100 gamers on top-rated NFL picks since its inception six years in the past. It went a scorching 24-14 on top-rated NFL picks final season, returning greater than $800. The mannequin additionally enters the 2021 season on an unimaginable 120-78 run on top-rated NFL picks that dates again to the 2017 season.

The mannequin additionally ranked within the High 10 on NFLPickWatch 4 of the previous 5 years on straight-up NFL picks and beat greater than 94 % of CBS Sports activities Soccer Decide’em gamers 4 instances throughout that span. Anybody who has adopted it’s approach up.

Now, it has turned its consideration to the most recent Week 1 NFL odds from Caesars and locked in picks for each NFL matchup. Head here to see every pick.

High Week 1 NFL predictions

One of many high Week 1 NFL predictions the mannequin recommends: The 49ers (-8.5) cowl the unfold towards the Lions. The 49ers have been among the finest highway groups within the NFL, successful seven of their eight regular-season highway video games on their solution to turning into NFC Champions two seasons in the past and capturing 5 of their six total wins on the highway final 12 months.

In the meantime, the Lions solely received as soon as at dwelling final season and Dan Campbell has been tasked with one other troublesome rebuild. The Lions completed twentieth in scoring and complete offense final season and changed quarterback Matthew Stafford with Jared Goff. In addition they let extensive receiver Kenny Golladay stroll in free company. That is going to place a whole lot of strain on a protection that ranked final in factors allowed and yards allowed a season in the past.

The mannequin is anticipating a wholesome 49ers offense to pile up over 450 yards of complete offense. The road has been transferring in the direction of San Francisco after opening at 7.5 factors, however the guests nonetheless cowl in over 50 % of SportsLine’s simulations.

One other one of many high Week 1 NFL picks from the mannequin: The Panthers (-4) cowl as dwelling favorites towards the Jets. After being chosen by the Jets with the No. 3 total within the 2018 NFL Draft and being traded away after simply three seasons, Darnold will get a right away probability at revenge with the Jets coming to go to him in his new dwelling in Charlotte.

Darnold has regarded snug within the preseason and is surrounded by far and away probably the most proficient group of talent gamers he is ever had. Christian McCaffrey is wholesome after lacking 13 video games a season in the past and will take the strain off Darnold by powering a strong working recreation whereas additionally being arguably one of the vital priceless receivers within the recreation too. The mannequin predicts that McCaffrey piles up over 130 yards of complete offense to assist the Panthers cowl in properly over 50 % of simulations.

Tips on how to make Week 1 NFL picks 

The mannequin has additionally made the decision on who wins and covers in each different recreation on the Week 1 NFL schedule, and it is calling for a Tremendous Bowl contender to go down arduous. You can only get every pick for every game at SportsLine.

So what NFL picks are you able to make with confidence? And which Tremendous Bowl contender goes down arduous? Try the most recent NFL odds under, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,900 since its inception, and discover out.

Week 1 NFL odds (by way of Caesars)

Sunday, Sept. 12

Steelers at Bills (-6.5, 48)

Featured Recreation | Buffalo Payments vs. Pittsburgh Steelers

Jets at Panthers (-4, 44.5)

Featured Recreation | Carolina Panthers vs. New York Jets

Jaguars at Texans (+3, 45.5)

Featured Recreation | Houston Texans vs. Jacksonville Jaguars

Cardinals at Titans (-3. 53.5)

Featured Recreation | Tennessee Titans vs. Arizona Cardinals

Chargers at Washington (-1, 44.5)

Featured Recreation | Washington Soccer Crew vs. Los Angeles Chargers

Eagles at Falcons (-3.5, 48.5)

Featured Recreation | Atlanta Falcons vs. Philadelphia Eagles

Seahawks at Colts (+3, 49)

Featured Recreation | Indianapolis Colts vs. Seattle Seahawks

Vikings at Bengals (+3, 47)

Featured Recreation | Cincinnati Bengals vs. Minnesota Vikings

49ers at Lions (+8.5, 46)

Featured Recreation | Detroit Lions vs. San Francisco 49ers

Browns at Chiefs (-5.5, 54.5)

Featured Recreation | Kansas Metropolis Chiefs vs. Cleveland Browns

Dolphins at Patriots (-3, 43.5)

Featured Recreation | New England Patriots vs. Miami Dolphins

Broncos at Giants (+3, 41.5)

Featured Recreation | New York Giants vs. Denver Broncos

Packers at Saints (+3.5, 49.5)

Featured Recreation | New Orleans Saints vs. Inexperienced Bay Packers

Bears at Rams (-7.5, 46.5)

Featured Recreation | Los Angeles Rams vs. Chicago Bears

Monday, Sept. 13

Ravens at Raiders (+4, 50.5)

Featured Recreation | Las Vegas Raiders vs. Baltimore Ravens | NFL odds, strains, picks, spreads, greatest bets, predictions for Week 1, 2021: High mannequin backing 49ers, Panthers


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