NFL odds, lines, picks, spreads, best bets, predictions for Week 1, 2021: Model backing 49ers, Panthers

Week 1 of the 2021 NFL schedule continues on Sunday and options a number of marquee matchups. The New England Patriots will start the Mac Jones period with an AFC East rivalry recreation towards the Miami Dolphins. The Patriots are three-point house favorites in Jones’ first profession begin within the newest Week 1 NFL odds from Caesars Sportsbook. The Week 1 NFL spreads additionally record the Chiefs as 5.5-point favorites over the Browns in a rematch of an AFC Divisional Spherical matchup from a season in the past. The Chiefs gained that recreation, however must you embrace them in your Week 1 NFL bets with Mahomes wholesome? All the Week 1 NFL traces are listed under, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 1 NFL picks now

The mannequin, which simulates each NFL recreation 10,000 instances, is up virtually $7,900 for $100 gamers on top-rated NFL picks since its inception six years in the past. It went a scorching 24-14 on top-rated NFL picks final season, returning greater than $800. The mannequin additionally enters the 2021 season on an unimaginable 120-78 run on top-rated NFL picks that dates again to the 2017 season.

The mannequin additionally ranked within the Prime 10 on NFLPickWatch 4 of the previous 5 years on straight-up NFL picks and beat greater than 94 p.c of CBS Sports activities Soccer Choose’em gamers 4 instances throughout that span. Anybody who has adopted it’s approach up.

Now, it has turned its consideration to the most recent Week 1 NFL odds from Caesars and locked in picks for each NFL matchup. Head here to see every pick.

Prime Week 1 NFL predictions

One of many prime Week 1 NFL predictions the mannequin recommends: The 49ers (-8.5) cowl the unfold towards the Lions. The 49ers have been probably the greatest highway groups within the NFL, successful seven of their eight regular-season highway video games on their approach to changing into NFC Champions two seasons in the past and capturing 5 of their six general wins on the highway final yr.

In the meantime, the Lions solely gained as soon as at house final season and Dan Campbell has been tasked with one other troublesome rebuild. The Lions completed twentieth in scoring and whole offense final season and changed quarterback Matthew Stafford with Jared Goff. In addition they let large receiver Kenny Golladay stroll in free company. That is going to place plenty of stress on a protection that ranked final in factors allowed and yards allowed a season in the past.

The mannequin is anticipating a wholesome 49ers offense to pile up over 450 yards of whole offense. The road has been transferring in the direction of San Francisco after opening at 7.5 factors, however the guests nonetheless cowl in over 50 p.c of SportsLine’s simulations.

One other one of many prime Week 1 NFL picks from the mannequin: The Panthers (-4) cowl as house favorites towards the Jets. Quarterback Sam Darnold has by no means had a lot energy alongside him throughout his NFL profession, however now he has star operating again Christian McCaffrey within the backfield. McCaffrey missed most of final season and was taken because the No. 1 general Fantasy soccer decide in most drafts. Darnold has the revenge issue on his aspect as he will get able to go up towards his former staff.

New York is enjoying below a first-year head coach, so it would take the Jets time to develop chemistry. They’ve a shaky secondary that Darnold ought to have success towards. SportsLine’s mannequin has Carolina masking this quantity in nicely over 50 p.c of simulations. 

Learn how to make Week 1 NFL picks 

The mannequin has additionally made the decision on who wins and covers in each different recreation on the Week 1 NFL schedule, and it is calling for a Tremendous Bowl contender to go down onerous. You can only get every pick for every game at SportsLine.

So what NFL picks are you able to make with confidence? And which Tremendous Bowl contender goes down onerous? Try the most recent NFL odds under, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,900 since its inception, and discover out.

Week 1 NFL odds (by way of Caesars)

Sunday, Sept. 12

Steelers at Bills (-6.5, 48)

Featured Recreation | Buffalo Payments vs. Pittsburgh Steelers

Jets at Panthers (-4, 44.5)

Featured Recreation | Carolina Panthers vs. New York Jets

Jaguars at Texans (+3, 45.5)

Featured Recreation | Houston Texans vs. Jacksonville Jaguars

Cardinals at Titans (-3. 53.5)

Featured Recreation | Tennessee Titans vs. Arizona Cardinals

Chargers at Washington (-1, 44.5)

Featured Recreation | Washington Soccer Staff vs. Los Angeles Chargers

Eagles at Falcons (-3.5, 48.5)

Featured Recreation | Atlanta Falcons vs. Philadelphia Eagles

Seahawks at Colts (+3, 49)

Featured Recreation | Indianapolis Colts vs. Seattle Seahawks

Vikings at Bengals (+3, 47)

Featured Recreation | Cincinnati Bengals vs. Minnesota Vikings

49ers at Lions (+8.5, 46)

Featured Recreation | Detroit Lions vs. San Francisco 49ers

Browns at Chiefs (-5.5, 54.5)

Featured Recreation | Kansas Metropolis Chiefs vs. Cleveland Browns

Dolphins at Patriots (-3, 43.5)

Featured Recreation | New England Patriots vs. Miami Dolphins

Broncos at Giants (+3, 41.5)

Featured Recreation | New York Giants vs. Denver Broncos

Packers at Saints (+3.5, 49.5)

Featured Recreation | New Orleans Saints vs. Inexperienced Bay Packers

Bears at Rams (-7.5, 46.5)

Featured Recreation | Los Angeles Rams vs. Chicago Bears

Monday, Sept. 13

Ravens at Raiders (+4, 50.5)

Featured Recreation | Las Vegas Raiders vs. Baltimore Ravens | NFL odds, traces, picks, spreads, greatest bets, predictions for Week 1, 2021: Mannequin backing 49ers, Panthers


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