NFL odds, lines, picks, predictions for Week 1, 2021: Proven model backing 49ers, Panthers

The brand new NFL season is simply across the nook and a loaded Week 1 NFL schedule will put speedy stress on bettors after a busy offseason. There are 5 video games on Sunday between groups within the NFL playoff image a season in the past, together with Bills vs. Steelers, Chiefs vs. Browns, and Rams vs. Bears on Sunday Night time Soccer. The newest Week 1 NFL odds from Caesars Sportsbook do not record any of the 16 video games on the schedule with a ramification of bigger than 7.5 factors.

There are seven Week 1 NFL spreads which might be a discipline purpose or much less, together with an necessary convention crossover matchup between the Colts and Seahawks. The Seahawks are 2.5-point highway favorites within the Week 1 NFL strains because the Colts take care of uncertainty surrounding Carson Wentz (COVID-19, foot). The entire Week 1 NFL strains are listed under, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 1 NFL picks now

The mannequin, which simulates each NFL recreation 10,000 occasions, is up virtually $7,900 for $100 gamers on top-rated NFL picks since its inception six years in the past. It went a scorching 24-14 on top-rated NFL picks final season, returning greater than $800. The mannequin additionally enters the 2021 season on an unbelievable 120-78 run on top-rated NFL picks that dates again to the 2017 season.

The mannequin additionally ranked within the High 10 on NFLPickWatch 4 of the previous 5 years on straight-up NFL picks and beat greater than 94 p.c of CBS Sports activities Soccer Choose’em gamers 4 occasions throughout that span. Anybody who has adopted it’s method up.

Now, it has turned its consideration to the newest Week 1 NFL odds from Caesars and locked in picks for each NFL matchup. Head here to see every pick.

High Week 1 NFL predictions

One of many high Week 1 NFL predictions the mannequin recommends: The 49ers (-7.5) cowl the unfold towards the Lions. San Francisco has dominated Detroit over time, successful 10 of its final 11 conferences towards the Lions. The 49ers have additionally been sensational on the highway, successful 12 of their final 17 away video games.

Detroit, in the meantime, has struggled mightily at dwelling, successful simply one in all its final 12 video games at Ford Subject. The mannequin has taken all of these traits under consideration and is anticipating San Francisco to cruise to victory in Week 1. The mannequin reveals San Francisco’s speeding assault gaining over 150 yards on the bottom, ensuing within the 49ers masking the unfold in practically 60 p.c of simulations. 

One other one of many high Week 1 NFL picks from the mannequin: The Panthers (-4.5) cowl as dwelling favorites towards the Jets. The Panthers have been 5-11 in Matt Rhule’s first season on the helm, however quarterback play was a significant problem all through the season and Christian McCaffrey was solely capable of play in three video games as he battled a wide range of accidents.

McCaffrey is wholesome, and after he put up 4,357 scrimmage yards and 32 touchdowns in 2018 and 2019, the Panthers are relying on him to be equally productive as soon as once more. In the meantime, quarterback Sam Darnold has seemed comfy after being acquired from the Jets through commerce this offseason and can play in essentially the most gifted offense he is ever been in, with McCaffrey, D.J. Moore, Robby Anderson and Terrace Marshall Jr. That is why the mannequin has the Panthers masking in effectively over 50 p.c of simulations, with McCaffrey piling up 130 scrimmage yards and scoring within the simulations.

How you can make Week 1 NFL picks 

The mannequin has additionally made the decision on who wins and covers in each different recreation on the Week 1 NFL schedule, and it is calling for a Tremendous Bowl contender to go down arduous. You can only get every pick for every game at SportsLine.

So what NFL picks are you able to make with confidence? And which Tremendous Bowl contender goes down arduous? Try the newest NFL odds under, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,900 since its inception, and discover out.

Week 1 NFL odds (through Caesars)

Thursday, Sept. 9 

Cowboys at Buccaneers (-7.5, 50.5)

Featured Sport | Tampa Bay Buccaneers vs. Dallas Cowboys

Sunday, Sept. 12

Steelers at Payments (-6.5, 50.5)

Featured Sport | Buffalo Payments vs. Pittsburgh Steelers

Jets at Panthers (-4.5, 43.5)

Featured Sport | Carolina Panthers vs. New York Jets

Jaguars at Texans (+3, 45)

Featured Sport | Houston Texans vs. Jacksonville Jaguars

Cardinals at Titans (-3. 51.5)

Featured Sport | Tennessee Titans vs. Arizona Cardinals

Chargers at Washington (+1.5, 44.5)

Featured Sport | Washington Soccer Group vs. Los Angeles Chargers

Eagles at Falcons (-3.5, 48)

Featured Sport | Atlanta Falcons vs. Philadelphia Eagles

Seahawks at Colts (+2.5, 49)

Featured Sport | Indianapolis Colts vs. Seattle Seahawks

Vikings at Bengals (+3.5, 48)

Featured Sport | Cincinnati Bengals vs. Minnesota Vikings

49ers at Lions (+7.5, 45.5)

Featured Sport | Detroit Lions vs. San Francisco 49ers

Browns at Chiefs (-6, 53)

Featured Sport | Kansas Metropolis Chiefs vs. Cleveland Browns

Dolphins at Patriots (-3, 44.5)

Featured Sport | New England Patriots vs. Miami Dolphins

Broncos at Giants (+2.5, 42.5)

Featured Sport | New York Giants vs. Denver Broncos

Packers at Saints (+3, 50)

Featured Sport | New Orleans Saints vs. Inexperienced Bay Packers

Bears at Rams (-7.5, 45)

Featured Sport | Los Angeles Rams vs. Chicago Bears

Monday, Sept. 13

Ravens at Raiders (+4.5, 51)

Featured Sport | Las Vegas Raiders vs. Baltimore Ravens | NFL odds, strains, picks, predictions for Week 1, 2021: Confirmed mannequin backing 49ers, Panthers


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