Colts vs. 49ers odds, spread, line: Sunday Night Football picks, predictions from NFL model on 125-85 run

The San Francisco 49ers (2-3) and the Indianapolis Colts (2-4) will duel it out in a primetime matchup on Sunday Evening Soccer. The Colts have received two of their final three video games and are at the moment second within the AFC South. San Francisco, in the meantime, seems to be to finish its three-game dropping streak in entrance of its dwelling crown. The 49ers have received 4 of their final six video games at dwelling in opposition to Indianapolis. 

Kickoff from Levi’s Stadium is ready for 8:20 p.m. ET. San Francisco is favored by 3.5-points within the newest Colts vs. 49ers odds from Caesars Sportsbook, whereas the over-under is 42. Earlier than locking in your 49ers vs. Colts picks, make sure you check out the NFL predictions from the red-hot SportsLine Projection Model. 

The mannequin, which simulates each NFL recreation 10,000 instances, is up virtually $7,700 for $100 gamers on top-rated NFL picks since its inception six-plus years in the past. It went a scorching 24-14 on top-rated NFL picks final season, returning greater than $800. The mannequin additionally enters Week 7 of the 2021 season on an unimaginable 125-85 run on top-rated NFL picks that dates again to the 2017 season.

The mannequin additionally ranked within the high 10 on NFLPickWatch 4 of the previous 5 years on straight-up NFL picks and beat greater than 94 p.c of CBS Sports activities Soccer Choose’em gamers 4 instances throughout that span. Anybody who has adopted it’s means up.

Now, the mannequin has simulated Colts vs. 49ers 10,000 instances and simply revealed its NFL picks and predictions. You can head to SportsLine now to see the model’s NFL picks. Now, listed here are a number of NFL odds and betting developments for Colts vs. 49ers on SNF:

  • Colts vs. 49ers unfold: San Francisco -3.5
  • Colts vs. 49ers over-under: 42 factors 
  • Colts vs. 49ers cash line: San Francisco -175, Indianapolis +150
  • IND: The Colts are 7-2 in opposition to the unfold of their final 9 street video games 
  • SF: The below is 5-0 in 49ers’ final 5 video games following a bye week 

Featured Recreation | San Francisco 49ers vs. Indianapolis Colts

Why the Colts can cowl

The Colts have made it tough for his or her opponents to attain a speeding landing this season. In actual fact, they’ve allowed the fewest speeding touchdowns within the NFL with just one. The Colts protection has two stud linebackers flying round. Bobby Okereke leads the staff in whole tackles with 51, together with 31 solo. The Stanford product had a monster recreation final week, recording a season-high 14 whole tackles with 9 solo. 

Darius Leonard is second on the staff in whole tackles with 45, together with 28 solo. Leonard has additionally caught two interceptions and recovered two fumbles on the 12 months. Indianapolis’ entrance 4 has additionally wrecked havoc, recording 12 sacks on the 12 months. Plus, the Colts have lined the unfold in 4 of their final 5 video games. 

Why the 49ers can cowl

Head coach Kyle Shanahan and the 49ers are optimistic that quarterback Jimmy Garoppolo will return from damage. Garoppolo suffered a calf damage in opposition to the Seattle Seahawks in Week 4, inflicting him to overlook the next recreation.

The 49ers have the sixth-ranked whole protection and permit 329.8 whole yards per recreation. This unit is led by All-Professional linebacker Fred Warner and defensive finish Nick Bosa. Warner leads the 49ers in whole tackles with 45, together with 29 solo. He has recorded a minimum of 9 tackles in 4 of the 5 video games performed. Bosa leads San Francisco with eight tackles for loss and 5 sacks. The Ohio State product has recorded a sack in 4 of the staff’s 5 video games on the 12 months. 

The right way to make Colts vs. 49ers picks 

SportsLine’s mannequin is leaning over on the purpose whole, projecting the groups to mix for 45 factors. The mannequin additionally says one facet of the unfold hits in nicely over 50 p.c of simulations. You can only see the model’s 49ers vs. Colts picks at SportsLine

So who wins 49ers vs. Colts on Sunday Evening Soccer? And which facet of the unfold hits in nicely over 50 p.c of simulations? Visit SportsLine now to see which side of the 49ers vs. Colts spread to jump on, all from the advanced model that is up over $7,900 on its NFL picks, and discover out. | Colts vs. 49ers odds, unfold, line: Sunday Evening Soccer picks, predictions from NFL mannequin on 125-85 run


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